TCS’ cutting-edge genomics research services

Applying multi-omics technology to personalize therapies

With the shift towards precision medicine, the focus of life sciences research is to capture, correlate, and connect a patient's molecular level information with diseases and treatments

Multi-omics, an approach that analyzes a combination of genomic, meta-genomic proteomic, epigenomic, phenomic, and omics data to discover new cures—is fast gaining ground. Life sciences organizations and research institutions are in the process of compiling genomic sequences and detailed molecular information of millions of people, to improve wellness and health outcomes.

TCS' Genomics Research Services enables life sciences organizations to derive actionable insights by providing sophisticated genome sequencing and analysis services enabled by its proprietary tools, algorithms, and platforms. TCS can help design and execute genomics studies that can lead to improved understanding of underlying biology, identification of new targets, and novel biomarkers which in turn lead to personalized therapies and patient stratification for clinical research or treatment selection.

Overview

Accelerating genomic interpretation in drug discovery

While significant improvements in DNA sequencing technologies help generate vast amounts of genomic data, clinical interpretation of this data, for instance, linking of DNA sequence anomalies or variations to the phenotypes and clinical conditions, is a tremendous challenge. The genome interpretation process, is encumbered by the many steps required to assemble raw sequences, perform quality assurance checks, create DNA annotations by integrating information from a multitude of sources, and prioritize variants relevant to the phenotypes of interest.

TCS’ focus is to use comprehensive data integration and analytics techniques to accelerate genomic interpretation in drug discovery and clinical research efforts, with services which ensure that genome sequencing experiments meet acceptable quality benchmarks, and data quality can be traced back to individual lab steps. TCS’ bioinformatics pipeline for the automated execution of genome as well as metagenome sequence analysis, includes a combination of open source and proprietary algorithms deployed on its in-house or client software platform.

What we offer

TCS uses its methodologies, tools, and platforms to design cutting-edge genomics research services

TCS' Genomics Research Services include:

• Strategy and design: Option analysis, study planning, protocol development, and execution methodologies
• Sequencing services: Nucleic acid extraction, library preparation (including custom library design), and sequencing
• Genome analysis: High quality reproducible genome data analysis with biologically meaningful interpretation
• Marker identification: Multivariate, model–based, and data mining approaches for potential biomarker candidates

TCS’ services support various applications such as target resequencing, transcript profiling, miRNA sequencing, and microbiome profiling (16 S rRNA sequencing), with sample processing from different samples including frozen tissue, blood, saliva, FFPE, stool, and so on.

How you benefit

TCS’ infrastructure and solutions assist in designing and conducting comprehensive genomic studies

• Employ advanced and patented genomics analysis solutions in the areas of text mining, variant or gene prioritization algorithms, and metagenomics analysis algorithms
• Access to a state-of-the-art genomics laboratory for sequencing and validation
• Refer to automated and expert-reviewed clinical interpretations of patient and individual genetic variations through proven pipelines
• Gain the ability to adopt a scalable model for varying research workload requirements